Palo Alto The selective stimulation of the cortex prmotorischen can improve the rehabilitation of t

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Palo Alto The selective stimulation of the cortex prmotorischen can improve the rehabilitation of the Muses. This emerges from a study in the Proceedings of the National Academy of Sciences (2014; doi: 10.1073 / pnas.1404109111) show that reveals the underlying biochemical Vernderungen.
The team led by Gary Steinberg of Stanford University experimented in Palo Alto with genetically modified Muses. The animals form the protein channelrhodopsin 2, the auslst a nerve impulse to a light stimulus from the outside towards the brain cells of the motor cortex. This developed by co-author Karl Deisseroth optogenetic techniques, cherokee researchers were able to selectively stimulate the motor cortex of mice over a trepanation, in which they had previously triggered a ischmischen stroke.
The Lhmungen the animals improved when the researchers regularly stimulated the motor cortex. The animals were then re-run in a position about a horizontal Spie, which they no longer had confidence after the stroke.
The examination of the brains showed that the stimulation of the cortex, the formation of neurotrophins on the other side of the brain auslste, demonstrating a long-range effect of the stimulation. The formation of Growth Associated Protein 43 was besides, increased, consider the neuroscientist as Plastizittsmarker in the brain. The stimulation of the motor cortex in healthy animals had no effect on the motor by the way, what speaks for a specific cherokee effect on the brain geschdigte.
Opto genetic experiments not come into question in humans, of course. A brain stimulation is, however, also possible via electrodes that are fed via a small trepanation in the brain. In Parkinson's disease, this treatment has become established in recent years. A similar treatment wre possible even in patients with severe Schlaganfllen. Prior to the start of clinical trials, however, Steinberg and co-workers want to explore which brain regions have to be best stimulated. rme / aerzteblatt.de Print Share Share
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