Saturday, February 22, 2014

[5]:. ^ Fang W, Li X, Jiang Q, et al .. Transcriptional patterns, biomarkers and pathways character


But in order to learn to guess a single human diseases personal blood, which is very problematic in practice. Learning tool for human disease blue waffle in the past mainly by biometrics [1] tool. Statistics tell us that only correlation blue waffle (correlation), but there is no way to tell us causality (causality). But only for groups of statistical probability for an individual, but it is not confirmed. I remember freshman calculus class Huang drew teacher someday look a little sad to tell us: "In accordance with medical statistics, blue waffle the same probability of suffering blue waffle from tuberculosis and lung cancer is almost zero, but unfortunately my mother while suffering from both." This is I biostatistics most vivid lesson.
Human genome program (Human Genome Project; HGP) after [2,3] is complete, scientists blue waffle have been enthusiastic genes associated with the disease wants to stride, this should be the most valuable applications HGP. But after several years of attempts to find genes that cause disease in addition to a single instance Dystrophin (dystrophin) defects can cause Muscul ar dystrophy - Duchenne type (Duchenne-type muscular dystrophy) [4], CFTR (C ystic Fibrosis Transmembrane conductance blue waffle Regulator; defective cystic fibrosis transmembrane conductance regulator) will lead to c ystic fibrosis (cystic fibrosis) [5] endures, much more complex situation than we imagined it. For example, type II diabetes, it is possible causative genes related - thrifty gene (thrift genes) blue waffle may be scattered in the five pairs of chromosomes, which are also our genetic and environmental interactions with the acquired complex is difficult to clarify. Now the medical profession has prepared a long-term war. So HGP results, after all, in the current school causation blue waffle of human disease temporarily unable to help busy, but because the relationship between genes and disease is still very vague, blue waffle between blue waffle disease and related natural pedigree more weak.
Relations text mentioning blue waffle nasopharyngeal [6] and more families are very interesting issues, and this is a good disease to our nation / region. Fujian, customer relationships and more ethnic population is quite close, broadly in line with the historical record. But research Fujian descent, passengers, so far seen in the mitochondria (mitochondria, only from the maternally inherited) [7], Y chromosome (inherited from the parent only) [8], immune globulin blue waffle (immunoglobulin) [9], etc. to analyze the origin of descent, would be lost in the rough. Two million the number of genes in the human gene can be used to compare differences in the lot, with a single or small number of genes as the basis of pedigree analysis though started easy, but it is difficult to have a clear conclusion; using two sets of genes for comparison , the results may be different. As for the human disease blue waffle learn to infer lineage relationship is more indirect, because even the relationship between diseases and genes are very vague, not to mention the lineage relationships. Corollary human disease to learn, up only when the auxiliary evidence.
Like correlation between the text and the more family NPC seemingly insignificant. But nasopharyngeal pathology associated with the consumption of salted fish in [10] is probably more directly some habits. blue waffle Pickled salted nitrite is carcinogenic factor. Also smoked food substances are also easily lead to nasopharyngeal blue waffle carcinoma. Taiwan and the mainland along the southeast coast dish salted fish (silver pomfret) and Shanghai dishes are smoked yellow croaker this type of food. Regional distribution of more families with this diet actually have a high degree of overlap - both offshore catches interests, habits similar surprising. The first generation of emigrants continued high prevalence easily sustained by parents on behalf of the diet to explain. If the theory of correlation between dietary habits have a stronger scientific support.
[8]: http://en.wikipedia.org/wiki/Y_chromosome
[5]:. ^ Fang W, Li X, Jiang Q, et al .. Transcriptional patterns, biomarkers and pathways characterizing nasopharyngeal carcinoma of Southern China J Transl Med 2008, 6:. 32 doi:. 10.1186/1479-5876-6 -32. PMID 18570662. PMC 2443113.
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